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Learn more about ARG1-D and treatment with LOARGYS

Learn more about ARG1-D and
treatment with LOARGYS

ARG1-D stands for arginase 1 deficiency (also referred to as hyperargininemia) and is a rare, inherited disease that causes a toxic build-up of an amino acid called arginine in the body

When we eat protein, our bodies break it down into amino acids, which we need to grow and stay healthy. This process results in waste (ammonia), which is not needed and is broken down by enzymes in the liver through a process called the urea cycle.

People with ARG1-D are partially or completely missing an enzyme called arginase 1, which is responsible for the last step of the urea cycle and breaks down arginine (an amino acid) to help the body get rid of it. Without this enzyme, arginine levels can rise to an unsafe level.

Too much arginine is harmful to the body and may significantly impact one’s health. People with ARG1-D may experience progressive symptoms including muscle tightness (spasticity), developmental delay, intellectual disabilities, seizures, impaired mobility, and potentially early death.

How LOARGYS can help

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LOARGYS works by acting as a replacement for the arginase 1 enzyme and is able to lower levels of arginine and help the body break it down and get rid of it

LOARGYS was proven to help both children 2 years of age and older and adults with ARG1-D in clinical studies:

  • LOARGYS helped to lower arginine levels and maintain lower levels over time
  • In clinical studies, LOARGYS was well tolerated

Resources and information

25PYM IMD008 LOARGYS Patient Brochure Digital Page
Patient Brochure
More information about ARG1-D and treatment with LOARGYS
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Patient Support Guide
Learn more about support offerings and access to LOARGYS
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If you are looking for more information about ARG1-D and urea cycle disorders (UCDs), visit the website below.

USE and IMPORTANT SAFETY INFORMATION

What is the most important information I should know about LOARGYS®?

Infusion reactions can happen during your infusion of LOARGYS. If you have a reaction while receiving LOARGYS, your doctor or nurse will slow or stop your infusion and treat your reaction. If you have a severe reaction, your doctor may stop treatment completely.

After eight weeks of once weekly intravenous LOARGYS, LOARGYS may be given by an injection under your skin at the doctor’s office or at home under the supervision of a doctor or nurse. Administration of LOARGYS by injection under the skin can cause a reaction. If you have a severe reaction, get medical help immediately.

LOARGYS is a prescription medicine that may cause serious side effects, including:

Serious Allergic Reactions Including Anaphylaxis.

Anaphylaxis is a sudden, severe, and life-threatening allergic reaction that can occur within seconds or minutes of taking LOARGYS.

Tell your doctor or nurse right away if you have any of the following symptoms during or after your treatment with LOARGYS:

  • fainting, dizziness, feeling light-headed (low blood pressure)
  • swelling of the face, eyelids, lips, mouth, tongue or throat
  • severe nausea, vomiting or diarrhea
  • trouble breathing, swelling of the throat, or chest tightness
  • weak and rapid pulse
  • skin rash, hives or itching

Before using LOARGYS, tell your doctor about all of your medical conditions, including if you:

  • have any of the symptoms listed in the section “What is the most important information I should know about LOARGYS?”
  • are pregnant or plan to become pregnant. It is not known if LOARGYS can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if LOARGYS passes into your breast milk.

Tell your doctor about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

LOARGYS® may cause serious side effects. See “What is the most important information I should know about LOARGYS?

The most common side effects of LOARGYS include: vomiting, fever, infusion related reactions (itching, arm swelling, and stomach pain), constipation, and hypersensitivity (facial swelling, rash, flushing, difficulty breathing).

These are not all the possible side effects of LOARGYS. Call your doctor for medical advice about side effects.

USE

LOARGYS is a prescription medicine used to treat high levels of arginine in the blood of adults and children 2 years and older with Arginase 1 Deficiency (ARG1-D), along with limiting the amount of protein in their diet.

Please read the full Prescribing Information for LOARGYS and discuss any questions that you have with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch or call 1-800-FDA-1088.

Please visit LOARGYS.com for more information.